 |
27th Annual Symposium on Nonhuman Primate Models for AIDS |  |
Hosted by Harvard Medical School, Sponsored by National Institutes of Health |
| Meeting Agenda | |
| All events are hosted at the Hyatt Harborside Hotel, Boston, unless stated otherwise. | |
| Tuesday, October 27, 2009 | |
| 8:00AM – 4:00PM | Directors' Meeting (at NEPRC) |
| 6:30PM – 8:00PM | Primate Pathology Workshop Registration & Hors d'oeuvres Reception (Queen Mary) |
| Wednesday, October 28, 2009 | |
| 8:00AM – 12:00PM | Directors' Meeting (at Hyatt Harborside, room TBA) |
| 8:00AM – 5:45PM | Primate Pathology Workshop (Grand Ballroom) |
| 4:00PM – 9:00PM | Registration (Lobby) |
| 6:00PM – 8:00PM | Welcome Reception (Skyline Ballroom) |
| 8:00PM – 9:00PM | Opening Address: (Grand Ballroom) Dr. Anthony Fauci, NIAID |
| Thursday, October 29, 2009 | |
| 7:00AM – 3:00PM | Registration (Ballroom Pre-function) |
| 7:00AM – 2:00PM | Poster set up (Harborside Pavilion) |
| 7:00AM – 8:00AM | Continental Breakfast (Michaelangelo) |
| 8:00AM – 5:00PM | Vendor Show (Ballroom Pre-function) |
| 8:00AM – 8:15AM | Opening Remarks and Keynote Introduction (Grand Ballroom), Dr. Amitinder Kaur and Dr. David Evans |
| 8:15AM – 9:00AM | Keynote Address (Grand Ballroom) Dr. Peter Parham, Professor, Stanford School of Medicine "Primate-specific regulation of natural killer cells" |
| 9:00AM – 12:15PM | Scientific Session 1: Virology (Grand Ballroom) Session Chair: Dr. Theodora Hatziioannou (Aaron Diamond AIDS Research Center) Session Co-Chair: Dr. Ronald Desrosiers (NEPRC, Harvard Medical School |
| 9:00AM – 9:30AM | Invited presentation by Theodora Hatziioannou "Towards an animal model for HIV-1/AIDS" |
| 9:30AM – 9:45AM | Rajnish Kaushik, University of Massachusetts Medical School "A cellular restriction dictates the permissivity of non-dividing monocytes/ macrophage to lentivirus and gammaretrovirus infection" |
| 9:45AM – 10:00AM | Ruth Serra-Moreno, New England Primate Research Center "Compensatory Genetic Changes Acquired by a Pathogenic Derivative of a Nef-deleted SIV Vaccine Strain Confer Resistance to Tetherin" |
| 10:00AM – 10:15AM | Thomas S. Postler, New England Primate Research Center "Signal Transduction by the Cytoplasmic Tail of gp41 of HIV and SIV" |
| 10:15AM – 10:30AM | Elizabeth Stansell, New England Primate Research Center "Galanthus nivalis agglutinin and Hippeastrum hybrid agglutinin select SIV variants that lack specific sites for high-mannose N-linked carbohydrate attachment" |
| 10:30AM – 10:45AM | Nagadenahalli B Siddappa, Dana Farber Cancer Institute "Natural Evolution of Clade C SHIV Neutralization Sensitivity from Tier 1 to Tier 2 is linked to differences in V1 and V2 Loop Sequences in Env" |
| 10:45AM – 11:15AM | Coffee Break (Michaelangelo) |
| 11:15AM – 12:15PM | Scientific Session 1: Virology (continued) (Grand Ballroom) |
| 11:15AM – 11:30AM | Brandon Keele, SAIC-Frederick, NCI-Frederick "Preferential transmission of SIVmac251 variants following intrarectal inoculation" |
| 11:30AM – 11:45AM | Yong Gao, Case Western Reserve Uiniversity "A novel system for rapid generation of various infectious SHIV viruses" |
| 11:45AM – 12:00PM | James M. Smith, Centers for Disease Control and Prevention "Generation of an infectious dual RT-Env SHIV in macaques" |
| 12:00PM – 12:15PM | Janice E. Clements, Johns Hopkins University School of Medicine "A SIV Macaque Model of HAART Identifies Viral Reservoirs" |
| 12:15PM – 12:25PM | Joseph Kemnitz, WNPRC "Primate portal" |
| 12:25PM – 1:25PM | Lunch (on your own), Cash Buffet in Skyline Ballroom |
| 1:25PM – 5:00PM | Scientific Session 2: Immunology (Grand Ballroom) Session Co-Chair: Dr. Ulrich von Andrian, Harvard Medical School Session Co-Chair: Dr. R. Paul Johnson, NEPRC, Harvard Medical School |
| 1:25PM –1:30PM | R. Paul Johnson "CHAVI announcement" |
| 1:30PM – 2:00PM | Invited presentation by Ulrich von Andrian "Imaging Anti-Viral Immune Responses in Lymph Nodes" |
| 2:00PM – 2:15PM | Roland Zahn, Beth Israel Deaconess Medical Center "Unusual maturation of CD4+ T cells in African green monkeys, a natural host of SIV infection" |
| 2:15PM – 2:30PM | Kenneth A Rogers, Yerkes NPRC, Emory Univ. School of Medicine "Immune enhancement of recombinant IL-15 in vivo by administration of IL-15Rα/Fc " |
| 2:30PM – 2:45PM | Beatrice Jacquelin, Institut Pasteur "Regulation of Type I Interferon-Stimulated Gene Expression in African Green Monkey Cells" |
| 2:45PM – 3:00PM | R. Keith Reeves, New England Primate Research Center "Evolution of SIVmac239Δnef-induced protection against vaginal challenge is associated with maturation of CD8+ T cell responses" |
| 3:00PM – 3:15PM | Thomas Friedrich, University of Wisconsin School of Veterinary Medicine "SIV elite controllers resist superinfection with multiple CD8+ T cell escape mutant viruses" |
| 3:15PM – 3:30PM | David T. Evans, New England Primate Research Center "Phenotypic Differences in Homing Receptor Expression on CD8+ T Cells Elicited by Intravenous versus Subcutaneous Inoculation Do Not Affect Protection Against an Intrarectal SIV Challenge" |
| 3:30PM – 4:00PM | Coffee Break (Michaelangelo) |
| 4:00PM – 5:00PM | Scientific Session 2: Immunology (continued) (Grand Ballroom) |
| 4:00PM – 4:15PM | Wendy W. Yeh, Beth Israel Deaconess Medical Center "Autologous neutralizing antibodies that select viral escape variants emerge late after SIV infection of rhesus monkeys" |
| 4:15PM – 4:30PM | Michael D. Alpert, New England Primate Research Center "Rapid, Standardized Titration of Antibodies Capable of Directing Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)" |
| 4:30PM – 4:45PM | Benjamin Bimber, University of Wisconsin "Ultra-deep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in SIV-infected macaques" |
| 4:45PM – 5:00PM | Natasa Strbo, University of Miami, Miller School of Medicine "SIV-Gp96-Ig vaccine induces high levels of adaptive mucosal CD8 effector cells in Rhesus macaques" |
| 6:00PM – 9:00PM | Poster Reception (Harborside Pavilion) |
| Friday, October 30, 2009 | |
| 7:00AM – 3:00PM | Registration (Ballroom Pre-function) |
| 7:00AM – 8:20AM | Continental Breakfast (Michaelangelo) |
| 8:20AM – 12:00PM | Scientific Session 3: Pathogenesis (Grand Ballroom) Session Co-Chair: Dr. Vanessa Hirsch, LMM, NIAID, NIH Session Co-Chair: Dr. Susan Westmoreland, NEPRC, Harvard Medical School |
| 8:20AM –8:25AM | Thomas Folks, SFBR "In memory of Jon Allan" |
| 8:30AM – 9:00AM | Invited presentation by Vanessa Hirsch "The Enigma of Disease Resistance to SIV of Natural Host Species" |
| 9:00AM – 9:15AM | Cristian Apetrei, University of Pittsburgh "SIVagm infection in patas monkeys (Erythrocebus patas). Host adaptation to SIV infection may result in virus extinction" |
| 9:15AM – 9:30AM | Vasudha Sundaravaradan, Seattle Biomedical Research Institute "Potential Th1 and Th2 functionality in double negative (CD3+/CD4-/CD8-) T cells during natural SIV infection of sooty mangabeys" |
| 9:30AM – 9:45AM | Namita Rout, New England Primate Research Center "Differential loss of natural killer T (NKT) cells in pathogenic and nonpathogenic simian immunodeficiency virus (SIV) infection" |
| 9:45AM – 10:00AM | Ivona Pandrea, University of Pittsburgh "Mucosal SIV transmission in natural hosts: susceptibility to infection depend on the availability of target cells at the mucosal sites" |
| 10:00AM – 10:30AM | Coffee Break (Michaelangelo) |
| 10:30AM – 12:00PM | Scientific Session 3: Pathogenesis (continued) (Grand Ballroom) |
| 10:30AM – 10:45AM | M. Christine Zink, Johns Hopkins University School of Medicine "SIV-infected macaques treated with highly active antiretroviral therapy (HAART) results in reduced virus replication and inflammation but persistence of viral DNA in CNS" |
| 10:45AM – 11:00AM | Simon M. Barratt-Boyes, University of Pittsburgh "Pathogenic SIV infection leads to rapid mobilization and death of plasmacytoid dendritic cells" |
| 11:00AM – 11:15AM | Kristina Abel, University of North Carolina "A nonhuman primate co-infection model of simian immunodeficiency virus (SIV) and Plasmodium fragile infection to study immune mechanisms leading to exacerbated disease and enhanced transmission" |
| 11:15AM – 11:30AM | Jacob D. Estes, SAIC-Frederick, Inc. "Damaged Intestinal Epithelial Integrity and Microbial Translocation in Simian Immunodeficiency Virus Infections" |
| 11:30AM – 11:45AM | Sieghart Sopper, German Primate Center "Viral replication but not microbial translocation correlates with immune activation and disease progression in SIV-infected macaques" |
| 11:45AM – 12:00PM | Mahesh Mohan, Tulane National Primate Research Center "Gastrointestinal disease in SIV-infected rhesus macaques is characterized by significant deregulation in microRNA expression" |
| 12:00PM – 1:30PM | Lunch (on your own) Cash Buffet in Skyline Ballroom |
| 1:30PM – 5:00PM | Scientific Session 4: Vaccines/Prevention (Grand Ballroom) Session Co-Chair: Dr. Dan Barouch, Beth Israel Deaconess Medical Center Session Co-Chair: Dr. David Evans, NEPRC, Harvard Medical School |
| 1:30PM – 2:00PM | Invited presentation by Dan Barouch "Mosaic HIV-1 Vaccines Expand the Breadth and Depth of Cellular Immune Responses in Rhesus Monkeys" |
| 2:00PM – 2:15PM | Neil Almond, National Institute of BIological Standards and Control "Live attenuated SIV: Characterising the Role of Vaccine Persistence in Protection" |
| 2:15PM – 2:30PM | Kazuyasu Mori, National Institute of Infectious Diseases "Long-term control of heterologous challenge infection in rhesus macaques vaccinated with live attenuated deglysoylated SIV by CD8+ cells mediated response" |
| 2:30PM – 2:45PM | Culina Slobodan, CEA, Division of Immuno-Virology "HIV DNA Vaccine Delivery in Association with Electroporation in the Skin of Nonhuman Primates" |
| 2:45PM – 3:00PM | George N. Pavlakis, National Cancer Institute at Frederick "Intramuscular DNA Delivery By Electroporation Leads to Greatly Enhanced Systemic and Mucosal Immune Responses and Control of SIVmac251 Challenge" |
| 3:00PM – 3:15PM | Anna Aldovini, Harvard Medical School "Mucosal SIV DNA-rMVA vaccination in female and in male rhesus macaques as an experimental approach to AIDS prevention" |
| 3:15PM – 3:30PM | Kara L Jensen, University of North Carolina at Chapel Hill "A Novel, Attenuated Recombinant Mycobacterium Tuberculosis HIV Vaccine Vector is Safe and Immunogenic in Infant Rhesus Macaques " |
| 3:30PM – 4:00PM | Coffee Break (Michaelangelo) |
| 4:00PM – 5:00PM | Scientific Session 4: Vaccines/Prevention (continued) (Grand Ballroom) |
| 4:00PM – 4:15PM | Amitinder Kaur, New England Primate Research Center "Immunogenicity and protective efficacy of recombinant replication-defective herpes simplex virus and DNA vector-based AIDS vaccines against SIV challenge in Rhesus macaques depends on the prime-boost" |
| 4:15PM – 4:30PM | Charles W Dobard, Centers for Disease Control and Prevention "Protection Against Repeated Vaginal SHIV Exposures in Macaques by a Topical Gel with an Integrase Inhibitor" |
| 4:30PM – 4:45PM | Ronald S. Veazey, Tulane National Primate Research Center "Extended release of vaginal CMPD167 for 28 days using a matrix vaginal ring device" |
| 4:45PM – 5:00PM | Ellen Kersh, Centers for Disease Control And Prevention "SHIV-specific T cell responses after Protection from SHIV Infection by PrEP" |
| 5:45PM | Buses depart for banquet (Hyatt Lobby) |
| 6:00PM – 10:00PM | Banquet (JFK LIbrary & Museum ) |
| 10:00 | Buses depart from Banquet to hotel |
| Saturday, October 31, 2009 | |
| 7:00AM – 8:30AM | Continental Breakfast (Michaelangelo) |
| 8:30AM – 11:00AM | Scientific Session 5: Genetics/Genomics (Grand Ballroom) Session Co-Chair: Dr. Mary Carrington, NCI, Frederick Session Co-Chair: Dr. Welkin Johnson, NEPRC, Harvard Medical School |
| 8:30AM – 9:00AM | Invited presentation by Mary Carrington "Immunogenetics of HIV Disease" |
| 9:00AM – 9:15AM | Samantha L. Finstad, Beth Israel Deaconess Medical Center "Influence of FCy-receptor polymorphisms on efficacy of antibody-mediated lymphocyte depletion in rhesus macaques" |
| 9:15AM – 9:30AM | Andrea Kirmaier, New England Primate Research Center "Primate Lentiviruses and Determinants of Sensitivity to Primate TRIM5alpha and TRIM5-Cyp A Proteins" |
| 9:30AM – 9:45AM | Julie A. Karl, University of Wsiconsin-Madison "MHC class I full-length allele discovery using Roche/454 Titanium amplicon sequencing technology to expand allele libraries in alternative nonhuman primate populations" |
| 9:45AM – 10:00AM | Sree Kanthaswamy, University of California-Davis "Detecting signatures of inter-regional and inter-specific hybridization among the Chinese rhesus macaque SPF population using single nucleotide polymorphic (SNP) markers" |
| 10:00AM – 10:30AM | Coffee Break (Michaelangelo) |
| 10:30AM – 11:00AM | Scientific Session 5: Genetics/Genomics (continued) (Grand Ballroom) |
| 10:30AM – 10:45AM | Shelby L. O'Connor, University of Wisconsin "Identification of MHC heterozygote advantage in SIV-infected Mauritian cynomolgus macaques " |
| 10:45AM – 11:00AM | Sallie R. Permar, University of Wisconsin "Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys " |
| 11:00AM – 12:00PM | Scientific Session: Late Breaker Abstracts (Grand Ballroom) |
| 11:00AM – 11:15AM | Betsy Ferguson, Oregon National Primate Research Center "New SNP arrays detect cryptic Chinese and hybrid animals among Indian-origin rhesus at NPRCs" |
| 11:15AM – 11:30AM | Omer Gokcumen, Brigham and Women's Hospital "High Resolution Discovery of Copy Number Variation among Rhesus-macaques" |
| 11:30AM – 11:45AM | Sampa Santra, Beth Israel Deaconess Medical Center, Harvard Medical School "Mosaic Vaccines Elicit CD8+ T Cell Responses in Monkeys that Confer Immune Coverage of Diverse HIV Strains" |
| 11:45AM – 12:00PM | Michael J. Lopker, University of Alabama at Birmingaham "Identification, Molecular Cloning and Characterization of Mucosally Transmitted SIVsmE660" |
| 12:00PM – 12:30PM | Closing Remarks and Preview of Upcoming Symposium (Grand Ballroom) Dr. Amitinder Kaur and David Evans, NEPRC Representative from Tulane NPRC, Host of the 28th Annual Symposium |